| The Effect of Ginkgo Biloba Extract (Ginexin(R)) on Experimental Central Retinal Vein Occlusion. |
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Kyung Sik Choi, Hyeong Gon Yu, Ju Hyun Kim, Su Jung Song, Young Ju Kim, Young Suk Yu, Hum Chung |
1Department of Ophthalmology, College of Medicine, SoonchunHyang University, Korea.
2Department of Ophthalmology, College of Medicine, Seoul National University Hospital, Korea. hgonyu@snu.ac.kr
3Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Korea.
4SK Pharma, Korea. |
| 실험적 망막중심정맥폐쇄에서 Ginkgo Biloba Extract (Ginexin(R))의 효과 |
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최경식 ( Choe Gyeong Sig ) , 유형곤 ( Yu Hyeong Gon ) , 김주현 ( Kim Ju Hyeon ) , 송수정 ( Song Su Jeong ) , 김영주 ( Kim Yeong Ju ) , 유영석 ( Yu Yeong Seog ) , 정흠 ( Jeong Heum ) |
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| Abstract |
PURPOSE
To investigate the beneficial effect of ginkgo biloba (Ginexin(R)) on ischemic retina model by retinal vein occlusion after photodynamic injury. METHODS: Ginkgo biloba 20 mg/kg/day, 100 mg/kg/day or carboxymethyl cellulose as a control group was administrated orally from 1week before the retinal vein occlusion to 2weeks after. After rose bengal was injected through vein of tail, retinal vein was occluded with argon laser. And then venous occlusion was confirmed by fluorescein angiogram. Rats were examined by using an indirect ophthalmoscopy and fluorescein angiography to detect reperfusion and new vessels. Eyeballs were enucleated for histological examination, retinal ganglion cell count and intravitreal glutamate level. RESULTS: The reperfusion of occluded vein was faster in the ginkgo biloba-treated group than the control group. In the ginkgo biloba-treated group, damage of the inner retina and TUNEL-positive cells were smaller than the control group on histologic examination. The concentration of retinal ganglion cells in the control group was lower than in the ginkgo biloba-treated group. CONCLUSIONS: Ginkgo biloba has protective effects in experimental ischemic retina after vein occlusion. |
| Key Words:
Ginkgo biloba;Ischemic retina;Vein occlusion |
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