Journal of the Korean Ophthalmological Society 2004;45(7):1081-1085.
Published online July 1, 2004.
The Effect of Intravitreal Triamcinolone Acetonide on Intraocular Pressure.
Yeon Hee Yang, Kyung Rak Kim, Suk Woo Yang, Hye Bin Yim
Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Our Lady of Mercy Hospital, Incheon, Korea. redeyek@hanmail.net
유리체내 트리암시놀론 주사 후 안압의 변화
양연희 ( Yeon Hee Yang ) , 김경락 ( Kyung Rak Kim ) , 양석우 ( Suk Woo Yang ) , 임혜빈 ( Hye Bin Yim )
Abstract
PURPOSE
To Investigate the effect of intravitreal triamcinolone acetonide on intraocular pressure (IOP) and the risk factors for its elevation. METHODS: This retrospective case study comprised 25 patients (26 eyes) with diabetic macular edema and 7 (7 eyes) with retinal edema due to branch retinal vein occlusion. The IOPs before and after intravitreal injection of 4 mg triamcinolone acetonide (postoperative 2 hours, 1 day, 2, 4, 8, and 12 weeks and 6 months) were recorded by Goldmann applanation tonometer. RESULTS: The average time to maximum IOP was 3.9 weeks and the difference of maximum post-injection IOP and pre-injection IOP was statistically significant (P<0.0001). IOP at post-injection 2 hours and 8 weeks was elevated significantly (p=0.01 and p=0.028, respectively). During follow up of 6 months, 8 eyes (24.24%) demonstrated an increase in IOP of 5 mmHg or greater, and 4 eyes (12.12%) of 10 mmHg or greater. IOP was more elevated in BRVO, younger age (< 60years) and males. All eyes responded to topical glaucoma medication. CONCLUSIONS: Transient IOP elevation can develop after intravitreal triamcinolone injection, especially from 4 to 8 weeks. Patients with risk factors for the elevation of IOP should be observed closely.
Key Words: Intraocular pressure;Intravitreal injection;Triamcinolone acetonide


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