Analysis of Electrically Evoked Potential in Rabbits with Polyimide Retinal Stimulator.

Kim, Seung Hyun; Seo, Jong Mo; Kim, Seong Joon; Kim, Eui Tae; Kim, Sung June; Yu, Young Suk; Chung, Hum

Original Article

Journal of the Korean Ophthalmological Society 2004;45(8):1363-1367.
Published online August 1, 2004.

Analysis of Electrically Evoked Potential in Rabbits with Polyimide Retinal Stimulator.

Seung Hyun Kim, Jong Mo Seo, Seong Joon Kim, Eui Tae Kim, Sung June Kim, Young Suk Yu, Hum Chung

¹Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. ysyu@snu.ac.kr
²Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
³School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Korea.
⁴Nano-Biosystem Engineering Research Center, Seoul, Korea.

폴리이미드 망막자극기를 삽입한 토끼의 전기유발전위 분석

김승현 ( Seung Hyun Kim ) , 서종모 ( Jong Mo Seo ) , 김성준 ( Seong Joon Kim ) , 김의태 ( Eui Tae Kim ) , 김성준 ( Sung June Kim ) , 유영석 ( Young Suk Yu ) , 정흠 ( Hum Chung )

Abstract

PURPOSE
Electrically evoked potential (EEP) was recorded in rabbits with polyimide-based, multichannel, microelectrode array (MEA) in their eyes, and was compared with the visual evoked potential (VEP) by flash light. METHODS: VEP was recorded under full-field flash light stimulation by 0. 6 J at 2 Hz, while EEP was recorded under electrical current stimulation of the retina by MEA. Latencies and shapes of N1, P100 and N2 in each evoked potential were compared. RESULTS: EEP was recorded in four of six rabbits. N1, P100 and N2 were observed in EEP on the electrical retina stimulation over 2.5 mA, and they resembled those of VEP. However, N1, P100 and N2 of EEP showed shorter latencies than those of VEP, by 15.1 msec (32.9%), 76.8 msec (38.3%) and 99.7 msec (60.1%) respectively. CONCLUSIONS: EEP by electrical retina stimulation with MEA was similar to VEP, indicating that MEA is suitable for the development of the artificial retina prototype. The shorter latencies of EEP should be considered in the parameters of the electrical stimulation of the retina.

Key Words: Artificial retina;Electrical stimulation;Evoked potential;Light stimulation