Effect of Alpha-Chymotrypsin on the Outflow Facility in Rabbit Eyes. |
Bong Leen Chang, Won Shik Youn |
Department of Ophthalmology, College of Medicine, Seoul National Univeristy, Korea. |
Alpha - Chymotrypsin 이 방수배출에 (房水排出) 미치는 영향 (影響) |
윤원식(Won Sik Yoon),장봉린(Bong Leen Chagn) |
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Abstract |
Alpha-chymotrypsin solutions, 200 unit/ml and 1,000 unit/ml, were injected into the anterior chamber of albino rabbit eyes fonowed by irrigation with normal saline after 3 minutes. Intraocular pressure was recorded by pressure transducer and pressure decay curve analysis was made to calculate the outflow facility according to the method of Eisenlohr and Langham. The follow-up periods were 30 days after the injection of the enzyme solution. By the injection of 0.25 ml of 200 unit/ml solution in 7 eyes, intraocular pressure showed almost no changes throughout the observation period. Outflow facility showed transient decrease during the first 3 to 5 days in some eyes. After the injection of 0.25 ml of 1,000 unit/ml solution in 3 eyes, transient elevation of the intraocular pressure was noted associated with decrease in outflow facility. In one eye, a marked rise in ocular pressure was found All the changes in intraocular pressure and outflow facility returned to the pre-treatment level within 30 days. It was concluded that high concentration of the alpha-chymotrypsin solution injected into the anterior chamber might cause disturbances in trabecular function causing elevation in intraocular pressure. |
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