| Comparison of Central Corneal Thickness after the Instillation of Topical Anesthetics: Proparacaine versus Oxybuprocaine. |
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Kyoung Sub Choi, Sang Min Nam, Hyung Keun Lee, Eung Kweon Kim, Kyoung Yul Seo |
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The Institute of Vision Research, Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea. seoky@yumc.yonsei.ac.kr |
| 국소마취제 점안 후 중심 각막 두께 측정치의 비교 : 프로파라케인과 옥시부프로케인 |
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최경섭,남상민,이형근,김응권,서경률 |
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The Institute of Vision Research, Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea |
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Correspondence:
Kyoung-Sub Choi, M.D. |
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| Abstract |
PURPOSE
To compare changes in human central corneal thickness after instillation of proparacaine with those after oxybuprocaine instillation, over a period of 10 minutes. METHODS: Eighteen healthy young participants were recruited. Baseline central corneal thicknesses were measured every 30 seconds for 10 minutes using a noncontact specular microscope. Changes in central corneal thickness were measured every 20 seconds for 10 minutes after the administration of one drop of 0.5% proparacaine into the right eye, and one drop of 0.4% oxybuprocaine into the left eye. RESULTS: Mean baseline central corneal thickness was 531 +/- 45 micrometer in the right eye and 531 +/- 42 micrometer in the left. The central corneal thickness after proparacaine instillation increased to 8.6 micrometer (4.5-12.6 micrometer, 95% CI) and then returned to baseline within 80 seconds. Central corneal thickness after oxybuprocaine instillation increased to 7.7 micrometer (3.6-11.2 micrometer, 95% CI) and then returned to baseline within 80 seconds. There was a second transient increase about 5 minute after proparacaine instillation but no additional transient increase after oxybuprocaine instillation. CONCLUSIONS: The severity of oxybuprocaine's effect on central corneal thickness is similar to that of proparacaine. Central corneal thickness instability may occur for 5 minutes after proparacaine administration. Therefore, changes in central corneal thickness after topical anesthetics instillation should be considered when measuring central corneal thickness. |
| Key Words:
Central corneal thickness;Oxybuprocaine;Proparacaine |
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