Journal of the Korean Ophthalmological Society 2005;46(6):938-944.
Published online June 30, 2005.
The Classification and Clinical Characteristics in Korean Patients with Avellino Corneal Dystrophy.
So Hyang Chung, Chang Yeom Kim, Eung Kweon Kim
Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. eungkkim@yumc.yonsei.ac.kr
아벨리노각막이상증으로 진단된 한국인 환자의 각막병변의 분류 및 임상양상
정소향,김창염,김응권
Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
Correspondence:  So-Hyang Chung, M.D.
Abstract
PURPOSE
To classify Avellino corneal dystrophy (ACD) into 3 groups by slit lamp photography and to evaluate the inter-group differences. METHODS: DNA analysis was performed in one member from each of 45 families who were clinically diagnosed as ACD. Corneal opacities were classified into mild (group I), moderate (group II), and severe (group III) based on slit lamp photograph. RESULTS: Six patients were confirmed as homozygous ACD and ninety-two as heterozygous ACD. One homozygous patient was revealed to have a novel phenotype. The age increased with increasing severity, and the proportion of females in group III was significantly higher than that of the other two groups (p=0.001). The prevalence of laser in situ keratomileusis (LASIK) increased in group III (p=0.001), and the incidence of pterygium increased in group I compared with the other two groups (p=0.025). CONCLUSIONS: ACD was aggravated with age, while pterygium and LASIK altered the natural course of ACD.
Key Words: Avellino corneal dystrophy;Laser in situ keratomileusis;Pterygium;Slit lamp photography


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