The Effect of Basic Fibroblast Growth Factor on the Vascularization of Porous Polyethylene Orbital Implant(Medpor(R)).

Kim, Kyung Rak; Jung, Chun Suk; Chung, Sung Kun

Original Article

Journal of the Korean Ophthalmological Society 2002;43(11):2258-2264.
Published online November 1, 2002.

The Effect of Basic Fibroblast Growth Factor on the Vascularization of Porous Polyethylene Orbital Implant(Medpor(R)).

Kyung Rak Kim, Chun Suk Jung, Sung Kun Chung

Department of Ophthalmology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. eyedoc@cmc.cuk.ac.kr

섬유모세포 성장인자가 다공성 폴리에틸렌 안와충전물(Medpor(R))의 혈관화에 미치는 영향

김경락 ( Kyung Rak Kim ) , 정천석 ( Chun Suk Jung ) , 정성근 ( Sung Kun Chung )

Abstract

PURPOSE
We investigated the effect of basic fibroblast growth factor (bFGF) on the vascularization rate of Medpor(R), a synthetic polyethylene orbital implant. METHODS: Medpor(R), pretreated or untreated with bFGF (25 ng/ml), was inserted into one eye of 18 New Zealand white rabbits and removed at 1, 2, and 4 weeks after implantation, and stained with hematoxylineosin and Masson's trichrome. Degree of vascularization was classified into zone 1 (or=4.6 mm ingrowth). RESULTS: One and two weeks after implantation, the percentage of the vascularization area were 56.25% and 68.75% in bFGF-untreated group, while those of bGFG-treated group were 75% and 80.56% respectively, but there were no statistical difference between bFGF-untreated and treated group. However, four weeks after implantation it was significantly higher in bFGF-treated group (84.38%) than in bFGFuntreated group (66.25%) (P<0.05). CONCLUSIONS: BFGF enhanced more and early fibrovascular ingrowth of Medpor(R).

Key Words: Basic fibroblast growth factor;Medpor(R);Vascularization