The Effects of ADCON(R)-L on the Adhesion after Strabismus Surgery.

Kim, Sang Kook; Choi, Mi Young

Original Article

Journal of the Korean Ophthalmological Society 2003;44(1):208-214.
Published online January 1, 2003.

The Effects of ADCON(R)-L on the Adhesion after Strabismus Surgery.

¹Department of Ophthalmology, College of Medicine Chungbuk National University, Korea. mychoi@med.chungbuk.ac.kr
²Chungbuk National University Medical Research Institute, Cheongju, Korea.

ADCON(R)-L이 사시수술 후 유착에 미치는 영향

김상국 ( Sang Kook Kim ) , 최미영 ( Mi Young Choi )

Abstract

PURPOSE
We investigated the effectiveness of ADCON-L in reducing the formation of adhesion after strabismus surgery in a rabbit model. METHODS: Bilateral recessions of superior rectus muscle (SR) were performed on 18 rabbits. ADCON-L was applied beneath and over the SR in 9 rabbits, while operative fields in the others were irrigated with a balanced salt solution (BSS). The degree of adhesion was recorded at 3 weeks postoperatively. All eyes were enucleated and histopathologic examination was done at 4 weeks postoperatively, and the degree of fibrous proliferation and inflammation were evaluated. RESULTS: A significant reduction in the degree of adhesion and fibrosis was noted in eyes treated with ADCON-L as compared with in those irrigated with BSS (p=0.003, p=0.028). However there was no statistical significance in the degree of inflammation between two groups (p=0.114). CONCLUSIONS: This study suggests that ADCON-L is effective in reducing postoperative adhesion for as long as 4 weeks after strabismus surgery in rabbits.

Key Words: ADCON-L;Adhesion;Rabbit;Strabismus surgery