Journal of the Korean Ophthalmological Society 2003;44(5):1188-1197.
Published online May 1, 2003.
Comparison of Corneal Substitutes Using PLGA, Collagen, Collagen with Amniotic Membrane Homologous Cornea.
Jung Hwan Oh, Sang Young Lee, Young Ha Kim, Jae Chan Kim
1Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea. imoh@chungang.md
2KIST Biomaterials Research Center, Seoul, Korea.
PLGA, Collagen, 양막부착 Collagen, 동종각막을 이용한 각막대체물질의 비교
오정환 ( Jung Hwan Oh ) , 이상영 ( Sang Young Lee ) , 김영하 ( Young Ha Kim ) , 김재찬 ( Jae Chan Kim )
Abstract
PURPOSE
To evaluate the biocompatibility of the corneal substitutes using PLGA scaffold, type I collagen film, type I collagen film combined with amniotic membrane (AM) and lyophilized homologous cornea in severely damaged ocular surface disease. METHODS: Rabbits were distributed into four experimental groups: (1) Type 1 collagen film: group A, (2) Type I collagen film combined with AM: group B, (3) lyophilized homologous cornea: group C, and (4) PLGA scaffold: group D. Corneal substitute-like discs in 7 mm diameter were inserted into the intralamellar stromal pockets of severely damaged corneas, and then corneal windows in 3 mm diameter were made on the upper lamellar cornea in groups A, B, and C. In 2 months of follow up, clinical evaluation including corneal neovascularization, opacity and transparency of the graft materials was performed, and the inflammatory reaction and fibroplasia were evaluated histologically. RESULTS: Corneal windows were completely reepithelized by postoperative day 3 to 9, and more rapid reepithelization was shown in groups B and C, Corneal neovascularization, opacity, and inflammation decreased more in groups B and C. No inflammation and transparent graft material was shown in group C. Histological studies showed many corneal stromal fibroblasts in and around graft materials in groups B and C. CONCLUSIONS: The type I collagen film combined with AM and the lyophilized homologous cornea were more stable in the severely damaged cornea. These results could be useful for the development of corneal substitutes.
Key Words: Amniotic Membrane;Lyophilized Cornea;PLGA Scaffold;Severely damaged ocular surface;Type I Collagen Film


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