The Clinical Results of Hemodilution Therapy for Retinal Vein Obstructive Disease.

Kim, Ung Soo; Yu, Seung Young; Kwak, Hyung Woo

Original Article

Journal of the Korean Ophthalmological Society 2003;44(6):1317-1322.
Published online June 1, 2003.

The Clinical Results of Hemodilution Therapy for Retinal Vein Obstructive Disease.

Ung Soo Kim, Seung Young Yu, Hyung Woo Kwak

Department of Ophthalmology, Kyung Hee University College of Medicine, Seoul, Korea. hwkwak@khmc.or.kr

망막정맥폐쇄환자에서 혈액희석요법에 관한 연구

김응수 ( Ung Soo Kim ) , 유승영 ( Seung Young Yu ) , 곽형우 ( Hyung Woo Kwak )

Abstract

PURPOSE
To evaluate the clinical results of isovolemic hemodilution for central retinal vein occlusion and branch retinal vein occlusion patients. METHODS: We have done phlebotomy and then infused same volume of hydroxyethyl starch to 6 CRVO and 5 BRVO patients, and control group(5 CRVO, 9 BRVO) was observed. We have checked hematocrit the next day. If the hematocrit was reached to final target, we stopped the hemodilution therapy. Anterior segment examination, visual acuity, fundus photography, fluorescein angiography, laboratory test was done. and compare the preoperative value to postoperative result. RESULTS: The final visual acuity improved in 10 eyes undergoing isovolemic hemodilution and control group 12 eyes. In fluorescein angiography, Arm to retina time is about 19.03+/-10.86%, venous filling time is 14.80+/-8.57%. The average reduction of hemoglobin is 22.12+/-4.33%, hematocrit is 22.74+/-4.71%. In laboratroy test, platelet, triglyceride, phospholipid, CSR, HDL is reduced. CONCLUSIONS: The retinal blood flow was improved by hemodilution in CRVO and BRVO patients. But further investigation and long-term follow up result was needed in this study.

Key Words: Branch retinal vein occlusion;Central retinal vein occlusion;CSR;HDL;Hemodilution