Journal of the Korean Ophthalmological Society 2003;44(6):1392-1396.
Published online June 1, 2003.
The Inhibitory Effect of Ticlopidine on VEGF Induced Corneal Neovascularization.
Young Kyu Park, Min Y Kim, Sun Ryang Bae
1Department of Ophthalmology, Daejeon St. Mary's Hospital College of Medicine, The Catholic University of Korea. sunrbae@yahoo.com
2Angiolab, Daejon, Korea.
VEGF로 유도된 각막혈관신생에 있어서 Ticlopidine의 억제효과
박영규 ( Young Kyu Park ) , 김민영 ( Min Y. Kim ) , 배선량 ( Sun Ryang Bae )
Abstract
PURPOSE
Ticlopidine, which has platelet inhibitory property, is currently used in peripheral arterial obstructive disease, ischemic stroke, and coronary artery disease. It is also known to have antiangiogenesis effect. We studied the effect of ticlopidine on rabbit corneal angiogenesis induced by VEGF. METHODS: In control group, a hydron pellet containing 300ng VEGF and phosphate buffered saline(PBS) was implanted intrastromally in the superior cornea. In treatment group, a hydron pellet containing 300ng VEGF and 375micro gram ticlopidine was implanted as the same manner. At 3, 5, and 7 day after implantation, we examined corneas under the microscope and estimated the angiogenesis score. RESULTS: At 5 and 7 day after implantation, ticlopidine-treated group had mean angiogenesis score of 27.9 and 49.1(p=0.014, independent t-test), while control group scored 13.0 and 25.3(p=0.004). CONCLUSIONS: In a rabbit corneal pocket assay, ticlopidine appears to have inhibitory effect on VEGF-induced corneal angiogenesis.
Key Words: Angiogenesis;Neovascularization;Ticlopidine;VEGF


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