Results of Combined Chemotherapy and Radiotherapy for Advanced Intraocular Retinoblastoma. |
In Young Chung, Eon Jeong Kim, Jong Moon Park, Ji Myong Yoo |
Department of Ophthalmology, Gyeongsang National University College of Medicine, Korea. YJM@nongae.gsnu.ac.kr |
망막모세포종의 항암화학요법과 방사선 병합치료 결과 |
정인영 ( In Young Chung ) , 김언정 ( Eon Jeong Kim ) , 박종문 ( Jong Moon Park ) , 유지명 ( Ji Myong Yoo ) |
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Abstract |
PURPOSE To report the result of combined chemotherapy and radiotherapy for 5 retinoblastoma patients. METHODS: Retrospective study of 5 patients (8 eyes) who were diagnosed with retinoblastoma of group III to V in the Reese-Ellsworth (R-E) classification was done. After 6 cycles of chemotherapy consisting of Vincristine, VP-16 (Etoposide) and Carboplatin, Radiotherapy (4500Gy/5weeks) was done. Neoaedjuvant therapy consisting of Nimustine and Carboplatin was done, and supplementary laser photocoagulation was done in 1 case. Mean follow-up period is 33 months. RESULTS: Significant reduction of tumor size and regression were observed in five eyes of R-E classification group V, and slight reduction of tumor size and regression were observed in three eyes of R-E classification groups III and IV. There was no recurrence and no new mass was detected. CONCLUSIONS: Combined chemotherapy, radiotherapy and supplementary therapy may save eyeballs which were diagnosed with retinoblastoma, even R-E classification group V. |
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