Visual Field Changes in Children with Vigabatrin Treatment.

Baek, Soon Chul; Cho, Moon Sik; Lee, Jae Ho

Original Article

Journal of the Korean Ophthalmological Society 2003;44(7):1600-1606.
Published online July 1, 2003.

Visual Field Changes in Children with Vigabatrin Treatment.

Soon Chul Baek, Moon Sik Cho, Jae Ho Lee

¹Department of Ophthalmology, Soonchunhyang University College of Medicine, Chunan, Korea. cms3445@hanmir.com
²Dangjin Woo-ri Eye Clinic, Dangjin, Korea.

소아에서의 Vigabatrin 복용 후 시야의 변화

백순철 ( Soon Chul Baek ) , 조문식 ( Moon Sik Cho ) , 이재호 ( Jae Ho Lee )

Abstract

PURPOSE
Recently, several reports have documented persistent visual field changes associated with long-term use of Vigabatrin, an antiepileptic drug. Epilepsy is a common disease in children, therefore we investigated perimetric changes in children who were on Vigabatrin treatment. METHODS: Total 36 eyes of 18 patients who had been treated with Vigabatrin were tested with Humphrey Field Analyzer. The visual fields were assessed using central 30-2 threshold test and peripheral 60-4 threshold test. RESULTS: In central 30-2 threshold tests, 13 eyes(40.6%) showed mild visual field constrictions and 4 eyes(12.5%) showed severe visual field constrictions. In peripheral 60-4 threshold tests, 23 eyes(71.8%) showed visual field changes. CONCLUSIONS: Asymptomatic visual field loss may develop in Vigabatrin-treated children. Regular examinations of the visual field is warranted for Vigabatrin-teated children.

Key Words: Children;Vigabatrin;Visual field constriction