Journal of the Korean Ophthalmological Society 2003;44(7):1675-1683.
Published online July 1, 2003.
The Effect of Amniotic Membrane Ointment on Prevention of Adhesion in Strabismus Surgery in Rabbits.
Dong Joon Lee, Jang Won Heo, Woo Chan Park, Kyung Won Yoo
1Department of Ophthalmology, Dong-A University College of Medicine, Korea.
2Department of Ophthalmology, Seoul Municipal Boramae Hospital, Korea.
가토안에서 상직근 후전술 후 유착방지를 위한 양막연고의 효과
이동준 ( Dong Joon Lee ) , 허장원 ( Jang Won Heo ) , 박우찬 ( Woo Chan Park ) , 유경원 ( Kyung Won Yoo )
The authors investigated the anti-inflammatory and the anti-fibrotic effect of amniotic membrane ointment on preventing adhesion in strabismus surgery in the rabbits. METHODS: Recession of superior rectus muscle was performed in 64 eyes of 32 rabbits and then the 32 rabbits were divided into 4 groups each 16 eyes of 8 rabbits. control group received no more treatment. 0.04% mitomycin C, base ointment, and amniotic membrane ointment were applied to the other trial groups respectively. Histopathologic studies was performed in 3 days, 2 weeks, 4 weeks, 12 weeks and evaluated the change of inflammation and fibrosis. The degree of inflammatory cell infiltration was evaluated on H and E stain and the degree of fibrosis was evaluated on Masson-trichrome stain. An immunohistochemical stain for alpha-smooth muscle actin was done for detection of myofibroblasts. RESULTS: On postoperation 3 days, 2 weeks, 4 weeks, the amniotic membrane ointment group and the mitomycin C group showed less inflammatory cell infiltration than control group(P<0.05). Masson-trichrome stain showed less fibrosis in the amniotic membrane ointment group and the mitomycin C group. The degree of immunohistochemical stain for alpha-smooth muscle actin was observed to be lower in the mitomycin C group and amniotic membrane ointment group than in the other groups during all period of observation. CONCLUSIONS: Amniotic membrane ointment might be effective adjuvant for prevention of postoperative adhesion in strabismus surgery.
Key Words: Adhesion;Amniotic membrane ointment;Strabismus surgery

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