Treatment of Conjunctival-Corneal Intraepithelial Neoplasia with Topical Mitomycin C.

Park, Hyun Jun; Lee, Ji Eun; Lee, Jong Soo; Park, Do Yoon

Case Report

Journal of the Korean Ophthalmological Society 2003;44(8):1924-1930.
Published online August 1, 2003.

Treatment of Conjunctival-Corneal Intraepithelial Neoplasia with Topical Mitomycin C.

Hyun Jun Park, Ji Eun Lee, Jong Soo Lee, Do Yoon Park

¹Department of Ophthalmology, Pusan National University College of Medicine, Pusan, Korea. jongsool@pusan.ac.kr
²Department of Pathology, Pusan National University College of Medicine, Pusan, Korea.

Mitomycin C (MMC) 점안액을 이용한 결막-각막 상피내 신생물의 치료

박현준 ( Park Hyeon Jun ) , 이지은 ( Lee Ji Eun ) , 이종수 ( Lee Jong Su ) , 박도윤 ( Park Do Yun )

Abstract

PURPOSE
To evaluate the therapeutic effect of topical mitomycin C (MMC) on the diffuse conjunctival-corneal intraepithelial neoplasia (CCIN). METHODS: Three patients histopathologically confirmed the conjunctival-corneal intraepithelial neoplasia (CCIN) received topical drop of 0.04% MMC four times daily for 2 to 4 weeks. Ocular complications and recurrence were evaluated under slit lamp biomicroscope. RESULTS: One case received topical drop of 0.04% MMC four times daily for 2 weeks and two cases of CCIN received for 4 weeks in the same manner. These lesions were completely regressed and did not recur under slit lamp biomicroscope during the follow-up of 18 months, 6 months, and 5 months, respectively. Other complications except superficial punctate keratitis and conjunctival injection did not develope and visual acuities have been improved. CONCLUSIONS: It appears that the application of topical MMC alone could be a primary effective treatment for diffuse conjunctival-corneal intraepithelial neoplasia (CCIN).

Key Words: Conjunctival-corneal intraepithelial neoplasia (CCIN);Topical mitomycin C