Laboratory Evaluation of Thrombophilic Factor in Retinal Vein Occlusive Disease.

Kim, Ung Soo; Kim, Sun Wook; Yu, Seung Young; Kwak, Hyung Woo

Original Article

Journal of the Korean Ophthalmological Society 2003;44(9):2004-2009.
Published online September 1, 2003.

Laboratory Evaluation of Thrombophilic Factor in Retinal Vein Occlusive Disease.

Ung Soo Kim, Sun Wook Kim, Seung Young Yu, Hyung Woo Kwak

Department of Ophthalmology, Kyung Hee University Hospital, Korea. hwkwak@khmc.or.kr

망막정맥폐쇄 환자에서 혈액응고인자 분석에 대한 연구

김응수 ( Ung Soo Kim ) , 김선욱 ( Kim Sun Wook ) , 유승영 ( Yu Seung Yeong ) , 곽형우 ( Gwag Hyeong U )

Abstract

PURPOSE
To evaluate the significance of thrombophilic factors in retinal vein occlusive diseases. METHODS: Thirty-two patients with retinal vein occlusion (19 patients at the age of 55 or less, 13 patients at the age of 56 or more) underwent laboratory evaluation for CBC, lipid profile, VDRL/TPHA, homocysteine, protein C activity, protein S activity, lipoprotein (a), platelet aggregation test, Factor V Leiden, lupus anticoagulant, anticardiolipin antibody, fibrinogen, and antithrombin III. RESULTS: The abnormal laboratory findings (high homocysteine, hyperlipidemia, thrombocytosis, lipoprotein (a), high ESR, and decreased protein S activity) were found more often in patients of 55 years or less than those of 56 or more. CONCLUSIONS: The thrombophilic factors were more common positive findings at or less than 55 years. Thrombophilic factor tests are recommended in young patients with retinal vein occlusion.

Key Words: Factor V Leiden;Homocysteine;Retinal vein occlusion;Thrombophilic factor;Young