| The Development of Injectable Intraocular Lens Using Thermosensitive Polymeric Hydrogel in Vitro and in Vivo. |
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Young Keun Han, Ji Won Kwon, Hee Young Kim, Jung Suk Kim, Chong Su Cho, Won Ryang Wee, Jin Hak Lee |
1Department of Ophthalmology, Seoul National University College of Medicine, Korea. jjhlee@plaza.snu.ac.kr
2Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Korea.
3Department of Ophthalmology, Seoul Municipal Boramae Hospital, Korea.
4School of Agricultural Biotechnology, Seoul National University, Korea. |
| 온도감응성 고분자 하이드로겔을 이용한 주입형 인공수정체의 개발을 위한 연구 |
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한영근 ( Han Yeong Geun ) , 권지원 ( Kwon Ji Won ) , 김희영 ( Kim Hui Yeong ) , 김정숙 ( Kim Jeong Sug ) , 조종수 ( Jo Jong Su ) , 위원량 ( Wi Won Lyang ) , 이진학 ( Lee Jin Hag ) |
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| Abstract |
PURPOSE
To evaluate the compatibility of poloxamer hydrogel as a material for the injectable intraocular lens in in vivo and in vitro model. METHODS: We determined the appropriate concentration of poloxamer hydrogel for injection through the examination of transparency and gelling temperature of this material and assess the technique of refilling the lens capsule and the postoperative findings. RESULTS: Poloxamer hydrogel showed excellent transparency compared with balanced salt solution(BSS) in air vinyl and 20% was identified as an appropriate concentration for direct lens refilling material. In vivo study, we injected poloxamer into the capsular bag after performing endocapsular phacoemulsification through the small anterior capsulotomy site. At 3 months follow up, we confirmed the excellent transparency and biocompatibility of poloxamer hydrogel. CONCLUSIONS: Poloxamer hydrogel was identified as an appropriate material for direct lens refilling material. |
| Key Words:
Direct lens refilling material;Injectable intraocular lens;Poloxamer hydrogel |
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