The Effect of Aqueous Humor Suppressants on the Duration of Intravitreal Perfluorocarbon Gas Bubble in Rabbits.

Ryu, Gyu Won; Kim, Young Il; Yun, Il Han

Original Article

Journal of the Korean Ophthalmological Society 2001;42(3):507-511.
Published online March 1, 2001.

The Effect of Aqueous Humor Suppressants on the Duration of Intravitreal Perfluorocarbon Gas Bubble in Rabbits.

Gyu Won Ryu, Young Il Kim, Il Han Yun

Department of Ophthalmology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

유리체강내 가스잔류기간에 대한 방수형성억제제의 효과

류규원(Gyu Won Ryu),김영일(Young Il Kim),윤일한(Il Han Yun)

Abstract

PURPOSE
Although the process by which intravitreal perfluorocarbon gas is absorbed is incompletely understood, it is known that considerable absorption of intravitreal perfluorocarbon gas occurs through the aqueous humor. The aim of the study was to evaluate experimentally the effect of topical aqueous humor suppressants on the intravitreal perfluorocarbon gas bubble duration. METHODS: After sulfur hexafluoride and perfluoropropane were injected intravitreally in ten rabbits, we measured the time of gas bubble disappearance in eyes treated with topical aqueous humor suppressants and in those not treated. RESULTS: The mean time(+/-SD) to disappearance of 0.4 cc of sulfur hexafluoride was 6.0+/-0.71 days, which was prolonged to 8.0+/-0.71 days with topical aqueous humor suppressants. The mean time(+/-SD) to disappearance of 0.2 cc perfluoropropane was 14.8+/-0.84 days, while it was prolonged to 22.0+/-1.58 days with topical aqueous humor suppressants. CONCLUSIONS: Sulfur hexafluoride and perfluoropropane intravitreal gas bubbles last longer in rabbit eyes treated with aqueous humor suppressants than in fellow control eyes.

Key Words: Aqueous humor supprassants;Intravitreal perfluorocarbon gas duration