| The Histopathologic Findings after Insertion of Biodegradible Polymer Sheet Made of PGA and PLGA/5-FU with Filtering Surgery in the Rabbit. |
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Young Joon Jo, Chang Sik Kim |
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Department of Ophthalmology, College of Medicine, Chungnam National University, Taejon, Korea. |
| 녹내장여과수술시 가토의 결막하에 삽입한 생분해성 고분자 / 5-Fluorouracil 복합체의 생체조직반응 |
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조영준(Young Joon Jo),김창식(Chang Sik Kim) |
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| Abstract |
PURPOSE
To evaluate the histopathologic changes after insertion of polymer made of poly- glycolic acid(PGA) and poly(lactic acid-co-glycolic acid)(PLGA)/5-FU following filtering surgery in the rabbit. METHOD: A polymer with 0.3 mm thickness made of PGA and PLGA/5-Fluorouracil(5-FU, 10% by weight) composite were made in a size of 3 x 7 mm. After full-thickness filtration surgery performed, PGA was inserted under the conjunctiva in group I, PLGA/5-FU was inserted in group II and none in control group. Twelve rabbit eyes were enrolled in each group. RESULT: Postoperatively, no serious complication was found in anterior segment. In the control eyes inflammatory cell reaction was minimal at 2 weeks after surgery and decreased thereafter. While severe fibrovascular tissue reaction with loss of conjunctival filtration space was noted at 2 and 4 weeks after surgery in group I, the filtration space was well maintained without fibrovascular tissue reaction until 4 weeks after surgery in group II. At 8 weeks after surgery, fibrous tissue reaction was observed in group I, but not in group II and contol. The polymer was not found and the filtration space was obliterated at 8 weeks after surgery in group I and II. CONCLUSION: PLGA/5-FU may be used as an effective adjunct to improve the success rate of the filtration surgery, without inducing serious fibrous tissue reaction. PGA was not suitable. |
| Key Words:
Biodegradible polymer;Filtering surgery;PGA;PLGA/5-FU |
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