Journal of the Korean Ophthalmological Society 2002;43(2):402-410.
Published online February 1, 2002.
The Effects of Amniotic Membrane for Prevention of Adhesion in Strabismus Surgery in Rabbits.
Woo Jin Jeung, Seung Joo Ha, Woo Chan Park, Kyung Won Yoo
Department of Ophthalmology, College of Medicine, Dong-A University, Pusan, Korea.
가토안에서 상직근 후전술 후 유착방지를 위한 양막이식의 효과
정우진 ( Woo Jin Jeung ) , 하승주 ( Seung Joo Ha ) , 박우찬 ( Woo Chan Park ) , 유경원 ( Kyung Won Yoo )
The formation of adhesion following strabismus surgery resulted in restrictive ocular motility dysfunction, recurrence, and failure of adjustable strabismus surgery. From these results, authors used amniotic membrane and evaluated its effect for prevention of adhesion in strabismus surgery in rabbit eyes. METHODS: Recession of superior rectus muscle was performed in 48 eyes of 32 rabbits. In 16 rabbits, both eyes were operated. Sixteen left eyes of 16 rabbits, control group, received no treatment after operation. In 16 right eyes of 16 rabbits, a sponge soaked in mitomycin C was applied after recession of superior rectus muscle. In 16 right eyes of other 16 rabbits, amniotic membrane transplantation was performed after procedure. After operation, 4 rabbits were sacrified in 24 hours, 2 weeks, 4 weeks, 3 months and evaluated the change of inflammation & fibrosis. The degree of inflammatory cell infiltration was evaluated on H & E stain and Masson-trichrome stain was performed to evaluate the degree of fibrosis. An immunohistochemical stain for alpha-smooth muscle actin was done for detection of myofibroblasts. RESULTS: On post-operation 24 hours and 2 weeks, the amniotic membrane-used group and the mitomycin C-used group showed less inflammatory cell infiltration than control group. On post-operation 2 weeks, 4weeks, and 3 months, amniotic membrane-used group and the mitomycin C-used group showed less fibrosis and fibroblast proliferation than control group (P<0.05). CONCLUSIONS: From these findings, authors conclude that the use of amniotic membrane transplantation after strabismus surgery is an effective method for prevention of postoperative adhesion.
Key Words: Adhesion;Amniotic membrane transplantation;Strabismus surgery

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