| Correlation between the Thyroid Associated Ophthalmopathy and Thyroid Function State. |
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Won Il Rhim, Seung Sik Choi, Helen Lew, Young Soo Yun |
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Department of Ophthalmology, Pochun CHA University College of Medicine, Pundang CHA Hospital, Sungnam, Korea. eye@cha.ac.kr |
| 갑상선 안병증과 갑상선 기능상태의 연관성 |
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임원일 ( Won Il Rhim ) , 최승식 ( Seung Sik Choi ) , 유혜린 ( Helen Lew ) , 윤영수 ( Young Soo Yun ) |
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| Abstract |
PURPOSE
To determine the prevalence of thyroid-associated ophthalmopathy (TAO) and the correlation between TAO and the thyroid function state. METHODS: 40 patients with TAO were selected among 2,000 patients of thyroid disease between September 1, 1995 and December 31, 2000, and classified by the Van Dyk's ''NOSPECS and RELIEF'' classification. T3, T4, TSH and Thyroid stimulating antibody (TSAb) levels were examined before and after treatment of TAO and thyroid disease. Relationship between TAO and thyroid function state was evaluated by using paired t-test and logistic regression test. RESULTS: The prevalence of TAO was about 2% in thyroid disease patients. Clinical manifestations of TAO were eyelid retraction (75%), exophthalmos (62.5%), soft tissue periorbital swelling (42.5%), diplopia and extraocular muscle restriction (20%), keratopathy (2.5%) and optic neuropathy (2.5%). Thyroid function state decided by T3, T4 and TSH level had no correlation with the improvement of TAO (p<0.05). But, TSAb level in improved TAO group (n=8) significantly decreased after treatment of TAO and thyroid disease (p<0.05). CONCLUSIONS: Thyroid function restoration may not help to improve the course of TAO. But, low TSAb level can be thought as a significant marker in improvement of TAO. |
| Key Words:
Thyroid disease;Thyroid-associated ophthalmopathy;Thyroid stimulating antibody |
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