The Effect of Mitomycin C in Endonasal Dacryocystorhinostomy.

Kim, Yun Tae; Chung, Wha Sun

Randomized Controlled Trial

Journal of the Korean Ophthalmological Society 2002;43(4):728-732.
Published online April 1, 2002.

The Effect of Mitomycin C in Endonasal Dacryocystorhinostomy.

Yun Tae Kim, Wha Sun Chung

Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. chungwha@med.yu.ac.kr

비강을 통한 누낭비강연결술에 있어서 mitomycin C의 효과

김윤태 ( Yun Tae Kim ) , 정화선 ( Wha Sun Chung )

Abstract

PURPOSE
To evaluate the effect of intraoperative 0.2 mg/ml mitomycin C application on the success of endonasal dacryocystorhinostomy. METHODS: One hundred patients (121 eyes) were randomly divided into two groups. Group A (50 patients, 59 eyes) was treated with 0.2 mg/ml mitomycin C application during endonasal dacryocystorhinostomy and group B (50 patients, 62 eyes) was operated without application of mitomycin C. In group A, mitomycin C soaked cotton swabs were applied to the osteotomy site for five minutes. The surgical success was defined as either symptom free from epiphora or good passage of syringing. RESULTS: After the follow-up period of 6~24 months (mean 10.2 months), average diameter of mucosal osteum measured 1.17+/-0.52 mm in group A and 1.00+/-0.61 mm in group B. Granuloma around mucosal osteum was noted in 20 eyes of group A and in 31 eyes of group B. Primary success rate was 93.2% in group A and 82.3% in group B. There was no significant difference in mucosal osteum size or success rate between the two groups. CONCLUSIONS: Adjunctive use of intraoperative mitomycin C may be useful to maintain larger osteotomy size and provide better success rate of endonasal dacryocystorhinostomy.

Key Words: Endonasal dacryocystorhinostomy;Mitomycin C;Mucosal osteum