| Confocal Microscopic Corneal Findings in the Normal Rabbit and Human. |
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Jong Soo Lee, Wook Hong Jong, Kyu Hyun Kim |
1Department of Ophthalmology, College of Medicine, Pusan National University, Pusan, Korea. jongsool@hyowon.pusan.ac.kr
2Department of Ophthalmology, College of Medicine, Korea University, Seoul, Korea |
| 공초점현미경에 의한 정상가토 및 정상인의 각막소견 |
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이종수 ( Jong Soo Lee ) , 홍종욱 ( Wook Hong Jong ) , 김현규 ( Kyu Kim Hyun ) |
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| Abstract |
PURPOSE
Although a confocal microscopy has been largely used, there has been no domestic report concerning the normal structure of rabbit and human cornea by confocal microscope. In this study, we investigated confocal microscopic morphology of normal cornea of rabbit and human. MEHTODS: Using confocal microscope (ConfoScan 2.0, Fortune Technology, Italy), cross-sectioned corneal images of the corneal epithelium, Bowman's layer, stromal layer (anterior, middle, and posterior keratocyte), Descemet 's membrane, and endothelium were examined in vivo. RESULTS: In normal rabbit corneas, the superficial epithelium was polygonal and Bowman's layer was wrinkled. The stromal keratocyte nuclei was elliptical anteriorly and was with less cellularity posteriorly. The endothelium of rabbit was uniform, hexagonal in shape and had highly reflective cell borders. In human corneas, the superficial epithelium had highly reflective nuclei and regular wing cell or subepithelial nerve plexus was visible. Bowman's layer was fold-like structure. The shape of anterior and middle keratocyte nuclei were polygonal, but posterior keratocyte was oval shape. Also the nerve plexus of middle stromal layer was visible and the nucleus of endothelial cell was reflective hexagonal shape. CONCLUSIONS: The normal corneal morphological findings were studied by confocal microscopy. These data might provide the useful informations for the diagnosis of corneal disease. |
| Key Words:
Confocal microscopy;Human;Rabbit |
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