| The Effect of Steroid and other Immunosuppressants on the Cataract and after-Cataract after Renal Transplantation. |
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Jin Hyuing Kim, Man Soo Kim |
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Department of Ophthalmology, Kangnam St. Mary's Hospital College of Medicine, The Catholic University Seoul, korea.mskim@cmc.cuk.ac.kr |
| 신장이식 후 사용된 스테로이드와 면역 억제제가 백내장 및 후발성 백내장 발생에 미치는 영향 |
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김진형 ( Jin Hyuing Kim ) , 김만수 ( Man Soo Kim ) |
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| Abstract |
PURPOSE
To evaluate the effect of systemic steroid and other immunosuppressants on the development of cataract and after-cataract in renal transplant patients. METHODS: We compared fourteen patients (22 eyes) who had undergone operation by one surgeon for cataract after renal transplnatation since 1991 and their follow-up period after cataract surgery was over 6months with the group that didn't have cataract after renal transplantation and the group that had cataract without systemic disease on the clinical aspect of cataract and after-cataract and also relationship with use of systemic steroid and immunosupressants. RESULTS: Most patients who underwent renal transplantation had posterior subcapsular opacity (81%) and their mean daily steroid dosage was statistically significantly higher than that of patients who didn't have cataract after renal transplantation(p<0.05). However, daily cyclosporin dosage and the use of azathioprine didn't have difference between the two groups. Additionally, the incidence and onset of after-cataract following cataract surgery had no statistically significant difference or correlations with daily steroid dosage(r=0.002) and daily cyclosporin dosage(r=0.16) or the use of azathioprine. CONCLUSIONS: Careful control of steroid dosage and early combination therapy with other immunosuppressants are considered to prevent the development of cataract in renal transplant patients. Further research on the effect of immunosupressants for after-cataract will be helpful to maintatin good visual outcome after cataract surgery. |
| Key Words:
After-Cataract;Cataract;Immunosuppressant;Renal transplantation;Steroid |
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