Journal of the Korean Ophthalmological Society 2002;43(7):1261-1268.
Published online July 1, 2002.
Expression of TGF-alpha, beta1, beta2 in Pterygial Mast cell.
Tae Hyung Kim, Seong Wook Seo, Jun Kyung Song
Department of Ophthalmology, College of Medicine, Gyeongsang National University, Korea. stramast@gshp.gsnu.ac.kr
군날개에서 나타나는 비만세포의 TGF-α, β1, β2의 발현양상
김태형 ( Tae Hyung Kim ) , 서성욱 ( Seong Wook Seo ) , 송준경 ( Jun Kyung Song )
Abstract
PURPOSE
To evaluate whether TGF-alpha, beta1, beta2 are expressed in pterygial mast cell and the difference between each growth factor exists. METHODS: We prepared 10 pieces each of excised normal conjunctiva, primary pterygium, recurrent pterygium from human eyes and then fixed those in 4% paraformaldehyde solution. The tissues were embedded in paraffin and slide samples taken from those. After that, we observed mast cells stained by immunohistochemistry against each of TGF-alpha,beta1 ,beta2 and compared the staining features between them, and we also confirmed metachromatic staining of the mast cell with toluidine blue. RESULTS: As compared with normal conjunctiva, in primary and recurrent pterygia, those counts of mast cells expressing TGF-alpha, beta1, beta2 were increased respectively with statistical significance and especially, those counts for TGF-beta1 in primary pterygium were 9 times as high as in normal conjunctiva. CONCLUSIONS: Pterygial mast cells are considered to play an important role in fibrovascular proliferation of pterygium by synthesizing and secretion of TGF-alpha, beta1, beta2 . Especially, TGF-beta1 is thought to play a more important role than TGF-alphaandbeta2 in primary pterygium.
Key Words: TGF-alpha;beta1;beta2;Mast cell;Pterygium


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