The Effects of Nicardipine in Experimentally-induced Retinal Ischemia-reperfusion Injury in Cats and Rabbits.

Kim, S Y; Kwak, M S; Lee, S H; Lim, J H

Original Article

Journal of the Korean Ophthalmological Society 1999;40(12):3361-3367.
Published online December 1, 1999.

The Effects of Nicardipine in Experimentally-induced Retinal Ischemia-reperfusion Injury in Cats and Rabbits.

¹Department of Ophthalmology, School of Medicine, Kyungpook National University.
²Department of Ophthalmology, Fatima General Hospital, Taegu, Korea.

실험적으로 유발한 망막 허혈 - 재관류 모델에서의 니카디핀의 효과

김시열(Si Yeol Kim),곽미선(Mi Seon Kwak),이상희(Sang Hee Lee),임정훈(Jung Hoon Lim)

Abstract

We investigated the effect of nicardipine on the retinal ischemia-reperfusion injury. After intravenous administration[30 microgram/kg] or intravitreal injection[10microgram] of nicardipine, total retinal ischemia for 60~90 minutes was induced in the left eye of cat or rabbit. Electroretinogram[ERG] including oscillatory potentials[OPs] was recorded from both eyes simultaneously prior to administration of nicardipine, and 1 hour, 1 day, 3 day, 1 week, and 2 weeks after reperfusion. In cats, the electroretinogram improved by intravenous or intravitreal injection of nicardipine. However, the degree was not statistically significant. In rabbits having intravitreal injection of nicardipine, marked improvement in recovery was achieved in post-reperfusion 1 hour b-wave and 3 day, 7 day SOP[summed amplitude of oscillatory potentials]. Difference of nicardipine effect on the retinal ischemiareperfusion injury between cats and rabbits can be attributed to the differences in the distribution of voltage-sensitive calcium channels.

Key Words: Nicardipine;Retinal ischemia-reperfusion injury