Vascular Occlusions Associated with Antiphospholipid Antibodies in Systemic Lupus Erythematosus.

Kim, In Taek; Na, Seung Chan; Lee, Kwang Ja

Original Article

Journal of the Korean Ophthalmological Society 2000;41(2):427-432.
Published online February 1, 2000.

Vascular Occlusions Associated with Antiphospholipid Antibodies in Systemic Lupus Erythematosus.

In Taek Kim, Seung Chan Na, Kwang Ja Lee

Department of Ophthalmology, School of Medicine, Kyungpook National University.

전신성홍반성루푸스에서 항인지질항체와 관련된 혈관폐쇄

김인택(In Taek Kim),나승찬(Seung Chan Na),이광자(Kwang Ja Lee)

Abstract

Antiphospholipid antibodies are found in association with collagen-vascular diseases including systemic lupus erythematosus[SLE]. As the laboratory tests suggest impaired coagulation, the patients having antiphospholipid Ab have been reported to be prone to develop thrombosis. The authors present three patients with antiphospholipid antibodies in SLE who had suffered from retinal vascular occlusions. Case 1 with central retinal vein occlusion who had both lupus anticoagulant and anticardiolipin Ab resulted in visual loss. Case 2 with branch retinal vein occlusion who was positive for only lupus anticoagulant experienced moderate visual disturbance. Case 3 with branch retinal artery occlusion who was positive for both lupus anticoagulant and anticardiolipin Ab died without ocular follow-up examination. We consider that SLE patients with the antiphospholipid Ab may be at high risk to develop disturbances in vision due to thromboembolism from a hypercoagulable state.

Key Words: Antiphospholipid Ab;Retinal vascular occlusion;Systemic lupus erythematosus