Journal of the Korean Ophthalmological Society 2000;41(3):731-736.
Published online March 1, 2000.
The Additive Effect of 0.2%Brimonidine[Alphagan]to Beta-Adrenergic Receptor Blockers in Patients with Open Angle Glaucoma.
Chang Woog Jeong, Gong Je Seong
1The Institute of Vision Research.
2Department of Ophthalmology, College of Medicine, Yonsei University, Youngdong Severance Hospital.
개방각 녹내장 환자에서 0.2% Brimonidine ( Alphagan (R) ) 추가 요법의 효과
정창욱(Chang Woog Jeong),성공제(Gong Je Seong)
Effect and side effects of adding 0.2% brimonidine to beta blockers was studied in 44 eyes of 32 glaucoma patients with inadequately controlled intraocular pressure[IOP]with beta blockers alone. Routine eye examination and IOP measurement were performed before the additive therapy. 0.2% brimonidine eye drops were topically applied three times a day with previously used beta blockers. IOP was measured at 1 week, 1 month, and 3months after the combined therapy. Mean IOP was 17.2 +/-1.8 millimeters of mercury before combined therapy ;13.5 +/-1.6 millimeters of mercury after 1 week, 14.3 +/-2.5 millimeters of mercury after 1 month and 13.6 +/-2.3 millimeters of mercury after 3 months of therapy. Side effects of combined therapy were oral dryness[25.0%], ocular pain[9.4%], and blurring[6.3%]. These results indicate that adding 0.2%brimonidine in patients treated with beta blockers causes a further reduction of IOP that may prove to be clinically useful in glaucoma therapy.
Key Words: 0.2% Brimonidine;Beta blockers;Glaucoma;IOP

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