Journal of the Korean Ophthalmological Society 2000;41(6):1304-1309.
Published online June 1, 2000.
The Characteristics of MUC 5 AC in the Corneal Tear Film.
Seung Eun Jung, So Young Kim, Kyoung Yul Seo, Jung Won Park, Su Yun Jeong, Je Kyung Seong, Eung Kweon Kim
1The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
2Cheil Eye Hospital, Taegu, Korea.
3Department of Larboratory Animal Medicine, Medical Research Center, College of Medicine, Yonsei University, Seoul, Korea.
4Brain Korea 21 Project for Medical Science, Yonsei University, Seoul, Korea.
MUC5AC의 눈물층에서의 존재 양상
정승은(Seung Eun Jung),김소영(So Young Kim),서경률(Kyoung Yul Seo),박중원(Jung Won Park),정수연(Su Yun Jeong),성제경(Je Kyung Seong),김응권(Eung Kweon Kim)
The mucous layer located on the cornea epithelial surface is mainly composed of mucin.It is unique in being composed of a central protein back bone surrounded by an outermost dense oligosaccharide matrix, yet its pre-cise composition is still unknown. Conjunctival goblet cells have been known to express the mucin MUC5AC. We attempted to reveal the presence of the secretory mucin MUC5AC as a component of the mucous layer in the rabbit corneal tear film. An antibody to a MUC5AC peptide was used to detect the MUC5AC mucin present in the tear film by immunohistochemistry. Human conjuncti-val impression cytology and immunohistochemistry were done with the same antibody. The MUC5AC mucin was observed in the precorneal tear film and con-junctival goblet cells by immunohistochemistry.The MUC5AC mucin is a component of the mucous layer and is produced by the goblet cells of con-junctiva.
Key Words: Cornea;Tear film;Mucin;MUC5AC

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