The Effect of Intravitreal and Subconjunctival Ciprfloxacin in the Treatment of S.Aureus Endophthalmitis.

Lee, Hyeon Il; Park, Hyeong Jun; Yi, Ka Young

Original Article

Journal of the Korean Ophthalmological Society 2000;41(9):1807-1814.
Published online September 1, 2000.

The Effect of Intravitreal and Subconjunctival Ciprfloxacin in the Treatment of S.Aureus Endophthalmitis.

Hyeon Il Lee, Hyeong Jun Park, Ka Young Yi

Department of Ophthalmology, National Medical Center, #18-79 Uljiro-6-ga, Chung-ku, Seoul, 100-196, Korea.

Staphylococcus Aureus 안내염에서 Ciprofloxacin 의 초자체강 내 주사와 결막하 주사의 치료효과 연구

이헌일(Hyeon Il Lee),박형준(Hyeong Jun Park),이가영(Ka Young Yi)

Abstract

To investigate the therapeutic effect of ciprofloxacin for the treatment of endophthalmitis, we used 18 rabbits with Staphylococcus aureus induce dendophthalmitis. The rabbits were assigned into three groups according to the treatment regimen; those who were not given any drug into group I, those who were given 100 microgram/ml ciprofloxacin intrvitreally into group II, and those who were given 2 mg/ml ciprofloxacin subconjunctivaly for 5 days into group III. We assessed clinical score, culture result of vitreous aspirate and pathologic finding of various ocular tissue. We found clinically significant decrease in clinical score in group II, but there were no significant differences in the vitreous culture and in the histologic findings among the study groups. In conclusion, we assume that intravitreal injection of ciprofloxacin may be the better treatment modality to treat endophthalmitis by S.aureus. In addition we still think there ought to be more studies as to the determination the dosage of ciprofloxacin and the use of steroid in combination.

Key Words: Ciprofloxacin;Endophthalmitis;Staphylococcus aureus