Effect of Oral Nifedipine on the Temporal Peripapillary.

Hyon, Joon Young; Lee, Jae Jun; Kim, Dong Myung

Original Article

Journal of the Korean Ophthalmological Society 2000;41(11):2386-2390.
Published online November 1, 2000.

Effect of Oral Nifedipine on the Temporal Peripapillary.

Joon Young Hyon, Jae Jun Lee, Dong Myung Kim

Department of Ophthalmology, Seoul National University College of Medicine #28 Yeongun-dong, Chongro-ku, Seoul, 110-744, Korea.

정상안압녹내장환자에서 Nifedipine 경구투여 후 유두주위망막의 혈류변화

이재준(Jae Jun Lee),김동명(Dong Myung Kim),현준영(Joon Young Hyon)

Abstract

Compromise of the tissue circulation plays a significant role in the development of optic nerve damage in normal-tension glaucoma (NTG). To evaluate the effect of nifedipine on the blood flow of peripapillary retina, blood flow of 7 NTG patients were measured using Heidelberg Retina Flowmeter before and 1 hour after oral administration of nifedipine 5 mg.Before treatment, NTG eyes had significantly reduced blood flow than control eyes (245.99+/-132.91 vs.303.38 +/-121.07, p=0.036).After treatment, nifedipine increased blood flow (245.99 +/-132.91 vs.329.37 +/-189.17, p=0.005)and decreased intercapillary square (49.78 +/-17.30 micrometer vs.47.13 +/-15.13 micrometer , p=0.049)significantly in the NTG eyes, but did not affect blood flow in the control eyes (303.38 +/-121.07 vs.309 +/-85.53, p=0.756).These results show that glaucomatous optic nerve damage is accompanied with blood flow deficits and nifedipine improve ocular hemodynamics in normal-tension glaucoma.

Key Words: Blood flow;Calcium channel blocker;Nifedipine;Normal-tension glaucoma