| Mechanism of Tissue Injury in Experimental Retinal Artery Occlusion: Morphological Study I. |
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Seung Jun Park, Shin Goo Kang, Young In Choi |
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Department of Ophthalmology, Eulji General Hospital #280-1 Hagye-1-dong, Nowon-ku, Seoul, 139-711, Korea. ksg4104@eulji.or.kr. |
| 망막동맥폐쇄 동물모델에서 조직손상기전 : 형태학적 연구 1 |
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박승준(Seung Jun Park),강신구(Shin Goo Kang),최영인(Young In Choi) |
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| Abstract |
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We used an animal model of laser-induced retinal artery occlusion to study the temporal and spatial patterns of tissue injury and to identify apoptosis-like morphologic changes.We performed fundus exam and fluorescein angiography for 2 weeks.Rats were sacrificed at 6 hours, 12 hours, 1 day, 2 days, 3 days, 7 days, and 14 days after arterial occlusion.The arterial reperfusion was seen from 6 hours to 4 days.We could observe vascular tortuosity and retinal hemorrhage in the fundus.Six hours after retinal arterial occlusion, there were a lot of cells which had chromatin condensation.One to three days membrane budding and apoptotic body were identifed after occlusion.Most of inner retinal layers were destroyed following 7days.These data demonstrated that retinal artery occlusion induces apoptotic cell death in the retinal ganglion cell and inner nuclear layer. |
| Key Words:
Apoptosis;Ischemic injury;Retinal ganglion cell;Retinalartery occlusion |
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