Trabeculectomy with Mitomycin C for High Risk Glaucoma : A Comparison between 0.2 and 0.4 mg/ml of Mitomycin C.

Kim, Kyu Sik; Moon, Jung Il

Original Article

Journal of the Korean Ophthalmological Society 2001;42(1):92-97.
Published online January 1, 2001.

Trabeculectomy with Mitomycin C for High Risk Glaucoma : A Comparison between 0.2 and 0.4 mg/ml of Mitomycin C.

Kyu Sik Kim, Jung Il Moon

Department of Ophthalmology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Korea.

고위험 녹내장의 섬유주절제술 시에 사용한 Mitomycin C 농도와 수술 성공률 비교

문정일(Jung Il Moon),김규식(Kyu Sik Kim)

Abstract

To raise the success rate of trabeculectomy in high-risk glaucomas, surgeons use various concentrations of Mitomycin C(MMC). We have used either 0.2 or 0.4 mg/ml for 4 minutes, so we intended to compare the success rate and complication between the two concentrations. Sixty-three eyes with high risk glaucoma on which MMC trabeculectomy was performed were divided into two groups. MMC concentration of 0.2 mg/ml(32 eyes)was used in the first group and 0.4 mg/ml(31 eyes)in the second group. Intraocular pressure less than 21 mmHg at postoperative 3 months with no treatment or with only one beta-blocker eyedrop application was regarded as success. The success rates showed no statistically significant difference:62.5%in one group and 58.1%in the other(p>0.05). However, the group with treatment of MMC 0.4 mg/ml showed higher incidence of complication such as hypotony, hyphema, leakage, progression of cataract and bleb rupture. In conclusion, MMC concentration of 0.2 mg/ml was safer than 0.4 mg/ml in the view of both success rate and complication development in trabeculectomy of high-risk glaucomas.

Key Words: High risk glaucoma;Mitomycin C;Trabeculectomy