Short-term Effect of 0.2% Brimonidine(Alphagan) in Normal Koreans.

Lee, Yun Seon; Seong, Gong Je

Original Article

Journal of the Korean Ophthalmological Society 1999;40(3):765-771.
Published online March 1, 1999.

Short-term Effect of 0.2% Brimonidine(Alphagan) in Normal Koreans.

¹The Institue of Vision Research, Yonsei University College of Medicine, Yongdong Severance Hospital.
²Department of Ophthalmology, Yonsei University College of Medicine, Yongdong Severance Hospital.

한국 정상인에서 단기간 사용한 0.2% Brimonidine(Alphaganⓡ) 의 효과

이윤선(Yun Seon Lee),성공제(Gong Je Seong)

Abstract

Brimonidine(Alphagan)is a relatively selective-adrenoceptor agonist that activates receptor in the ciliary body, which lowers intraoculat pressure by decreasing aqueous production and increasing uveoscleral outflow. We investigated the short-term intraocular pressure lowering effect and side effect of 0.2% brimonidine in 8 eyes in 8 normal volunteers. Brimonidine was administered every 8 hours for 7 days. The intraocular pressure, pupil size, pulsatile ocular blood flow of both eyes, blood pressure, and pulse rate were obtained 2, 4 and 8 hours, and 1 and 7 days after instillation. The mean intraocular pressure was lowered in both eyes. The blood pressure, pulse rate, and pupil size were not changed before and after the instillation. The pulsatile ocular blood flow was not changed either, The only side effect which patients complanined of was nasal stuffiness in two of the patients. We concluded that 0.2% brimonidine is a good ocular hypotensive drug that has an intraocular pressure lowering effect in normal Koreans and also has few side effects.

Key Words: 0.2% brimonidine;Intraocular pressure;Pulsatile ocula blood folw;Side effect