Journal of the Korean Ophthalmological Society 1999;40(4):915-920.
Published online April 1, 1999.
Effect of Dorzolamide on Corneal Endothelium.
In Ki Park, Ji Young Kim, Won Ryang Wee, Dong Myung Kim
Department of Ophthalmology, College of Medicine, Seoul National University.
Dorzolamide가 각막내피에 미치는 영향
박인기(In Ki Park),김지영(Ji Young Kim),위원량(Won Ryang Wee),김동명(Dong Myung Kim)
Abstract
The purpose of this study was to investigate the effect of 2% dorzolamide, a topical carbonic anhydrase inhibitor, on corneal endothelium. Corneal endothelial permeability, central corneal thickness, central corneal endothelial cell density and intraocular pressure were measured in both eyes before(baseline) and after the use of 2% dorzolamide t.i.d. in one eye for one week. There was significant decrease in intraocular pressure(p=0.04) after the use of 2% dorzolamide t.i.d. for one week, but there were no significant changes in corneal endothelial permeability, central corneal thickness and central corneal endothelial cell density(p>0.05 in all).
Key Words: Corneal endothelial permeability;Corneal thickness;Dorzolamide


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