| Efficacy of Intraocular Pressure Decrease and Safety after Topical 1%Brinzolamide (Azopt) Instillation on Normal Eyes. |
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Dong Yeol Lee, Dong Won Lee, Sae Heun Rho |
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Department of Ophthalmology, College of Medicine, Dong-A University, Pusan, Korea . |
| 정상안에서 1%brinzolamide(Azopt)국소점안 후 안압하강효과와 안전성에 관한 연구 |
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이동열(Dong Yeol Lee),이동원(Dong Won Lee),노세헌(Sae Heun Rho) |
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| Abstract |
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The aim of this study is to evaluate intraocular pressure (IOP)-lowering effects and side effects of 1%brinzolamide in its single use, and also in combined use with beta-blocker. Eighty normal eyes of 40 persons were randomized and divided into two groups: group A and B,20 persons each. In group A, patients had brinzolamide on unilateral eyes (subgroup A-1), and normal saline on the contralateral eyes (subgroup A-2). In group B, patients had 0.5% timolol and 1%brinzolamide on unilateral eyes and 0.5% timolol only on the contralateral eyes. IOP was measured before, 1/2,1,2,4 and 8 hours after instillation, respectively, and adverse effects were monitored. In both subgroups A-1 and B-1, the decrease of IOP was statistically significant compared with controls between 30minutes and 8 hours after instillation. Subgroup A-1 showed maximal decrease of IOP (22.2%) at 4 hours after instillation,while subgroup B-1 showed maximal decrease of IOP (48.3%) at 2 hours after instillation. Moreover,subgroup B-1 showed 12.1% of additional IOP-lowering effect on the average, compared with subgroup B-2. Out of the few adverse effects reported reported, bitter taste was the most common complaint. Brinzolamide might be used as a single agent or as an adjunct to betablocker for decreasing IOP in glaucoma patients. But further evaluation on more controls and patients of glaucoma or ocular hypertension through longer follow-up is required to support its clinical use. |
| Key Words:
Brinzolamide;IOP;Adverse effect |
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