Experimental Branch Retinal Vein Occlusion in Albino Rats.

Ham, Don Il; Kim, Seong Jun; Chang, Kwang; Chung, Hum

Original Article

Journal of the Korean Ophthalmological Society 1997;38(7):1194-1202.
Published online July 1, 1997.

Experimental Branch Retinal Vein Occlusion in Albino Rats.

Don Il Ham, Seong Jun Kim, Kwang Chang, Hum Chung

¹Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
²Department of Ophthalmology, Samsung Medical CenterChangs Eye Clinic, Incheon, Korea.

흰쥐에서의 실험적 망막정맥분지폐쇄

함돈일(Don Il Ham),김성준(Seong Jun Kim),장광(Kwang Chang),정흠(Hum Chung)

Abstract

The retinal vein occlusion is one of the most common retinal diseases, and the establishment of animal model in rats will be a great help for further study. We occluded branch retinal veins with rose bengal dye injection followed by argon-green laser photocoagulation in albino rats. Retinal vein occlusion was maintained over 1 day in 35 eyes out of 47, maximally over 5 days. Retinal tissue damage was confined to the photocoagulated areas in most eyes and the loss of ganglion cells began when the occlusion persisted over 1 day. If the reproducibility is further increased, this will be a good animal model of retinal vein occlusion in albino rats.

Key Words: Retinal vein occlusion;Animal model;Rose bengal;Laser Laser photocoagulation