Effect of Practolol on Ocular Tension in Rabbits.

Lee, Song Hee

Original Article

Journal of the Korean Ophthalmological Society 1974;15(2):114-118.
Published online February 1, 1974.

Effect of Practolol on Ocular Tension in Rabbits.

Song Hee Lee

Department of Ophthalmology, College of Medicine, Busan National University Busan, Korea.

Practolol 이 정상 가토안압에 미치는 영향

이송희 ( Song Hee Lee )

Abstract

A trial with eye drops of practolol, 0.2% and propranolol, 0.1%, and intravenous injection of practolol, 1-4mg/kg. and propranolol, 0.5-2mg/kg. in rabbits was done for the changes of ocular tension. Ocular tension was estimated by Schotz tonometer. The E.C.G. was recorded before and after treatment of the above drugs. In the rabbits all of doses of practolol, topically and systemically applied failed to reduce ocular tension, but propranolol reduced slightly ocular tension which was suggested that the lowering of ocular tension was mediated by its local anesthetic activity.