| Comparative study of Eosinophil and Eosinophil Cationic Protein (ECP) of Tears and Sera in Children with Allergic Conjunctivitis. |
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Seoung Bock Lee, Jung Chul Shin, Dong Seob Kim, Jae Won Oh |
1Department of Ophthalmology, College of Medicine, Hanyang University, Seoul, Korea.
2Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. |
| 소아 알레르기 결막염환자의 눈물과 혈청에서의 호산구치와 Eosinophil Cationic Protein ( ECP ) 치의 비교연구 |
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이승복(Seoung Bock Lee),신정철(Jung Chul Shin),김동섭(Dong Seob Kim),오재원(Jae Won Oh) |
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| Abstract |
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The objective of this study is to measure eosinophil count and Eosinophil Cationic Protein (ECP) levels of tears and sera in patients with acute allergic conjunctivitis and normal subjects and to assess the correlation of this mediator with allergic conjuctivitis and the clinical usefulness. Seventeen subjects were selected on the basis of clinical manifestation, history, skin prick test, total IgE. Serum IgE and eosinophil count were increased in 10patients, and eosinophilia in conjunctival epithelium were present in 11subjects. ECP in tears were increased in patients significantly (12.0+/-8.0 vs 3.9+/-3.8ng/ml,p=0.01), but not in serum (52.5+/-43.1 vs 28.3+/-25.9ng/ml). There was significant relationship beween serum and tear eosinophil count(p=0.004,r=0.66). But there was no significant correlation between eosinophil count and ECP in serum (p>0.05m r=0.19), and no significant correlation between eosinophil count of conjectival epithelium and tears ECP (p=0.043, r=0.05). In conclusion, ECP in tears may be very important role in allergic conjunctivitis and is more reliable indicatior of diagnosis clinically rather than eosinophil count in tear and conjunctival epithelium. |
| Key Words:
Allergic conjunctivitis;Eosinophil;Eosinophil Cationic Protein (ECP) |
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