The Effects of 0.5% Apraclonidine on Optic Nerve Head and Peripapillary Retinal Microcirculation.

Kim, Tae Woo; Kim, Dong Myung; Wee, Won Ryang; Lee, Jin Hak; Chang, Bong Leen

Original Article

Journal of the Korean Ophthalmological Society 1997;38(12):2172-2176.
Published online December 1, 1997.

The Effects of 0.5% Apraclonidine on Optic Nerve Head and Peripapillary Retinal Microcirculation.

Tae Woo Kim, Dong Myung Kim, Won Ryang Wee, Jin Hak Lee, Bong Leen Chang

Department of Ophthalmology, Seoul National University Hospital.

0.5% apraclonidine 이 시신경유두 및 유두주위 망막의 미세순환에 미치는 영향

김태우(Tae Woo Kim),김동명(Dong Myung Kim),위원량(Won Ryang Wee),이진학(Jin Hak Lee),장봉린(Bong Leen Chang)

Abstract

To examine the effects of 0.5% apraclonidine on optic nerve head (ONH) and peripapillary microcirculation, scanning laser Doppler flowmetry was performed before and 1 honr, and 3 hours after administration of 0.5% apraclonidine in 10 healthy subjects. In each occasion, 3 scans were obtained. Hemodynamic parmeters (volume, flow, and velocity0 were found at 8 locations, 4 in the neural rim and 4in the peripapillary retina. The intraocular pressure was reduced significantly in apraclonidine-treated eyes by 15.4% (p<.05) at 1 hour and 30.1% (p<.01)at 3 hours after administration. There was no significant change in the volume, flow or velocity of ONH and peripapillary retinal blood flow after apraclonidine administration. In conclusion, single-dose of topical apraclonidine 0.5% in healthy subjects does not have adverse effects on the microcirculation in ONH and peripapillary retina.

Key Words: Apraclonidine;Microcirculation;Scanning laser Doppler flowmetry