| The Change of Interleukin-1beta & Nitric Oxide in Tear after Excimer Laser Photorefractive Keratectomy. |
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Ji Han Ryou, Noh Young Bae, Kyung Hwan Shyn, Jae Chan Kim |
1Department of Opthalmology, College of Medicine, Chung-ang University, Seoul, Korea.
2Department of Opthalmology, National Police Hospital, Seoul, Korea.
3Department of Opthalmology, Kong Eye Center. |
| 엑시머레이져 각막절제술 후 눈물에서의 Interleukin-1β와 Nitric oxide 발생량의 변화 |
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류지한(Ji Han Ryou),배노영(Noh Young Bae),신경환(Kyung Hwan Shyn),김재찬(Jae Chan Kim) |
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| Abstract |
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This study was performed to investigate the amount of IL-1beta & NO in tear film after Excimer laser PRK and to determine whether NO induces cytotoxicity associated with apoptosis of keratocytes. Twelve myopes underwent PRK and were divided into 3 groups according to spherical equivalent. IL-1beta and NO production were measured at preop and postop 1, 4, 7 days, and expression of NOS and apoptosis of keratocytes were evaluated in the corneas of rats at 2 days after PRK. IL-1beta and NO production were significantly increased at postop 1 day(p<0.01) and then gradually decreased to preop levels at postop 7 days. The corneas of rats at 2 days after PTK revealed increased expression of NOS(iNOS, bNOS) and increased apoptosis of keratocytes in stroma of cornea. The degree of corneal opacity and NO production at postop 1 days were increased, positively correlated to ablation depth. It is suggested that NO production induced by IL-1beta may be related with apoptosis of keratocyte, which can influence on the corneal opacity after PRK. |
| Key Words:
Excimer laser PRK;Interleukin-1beta;Nitric oxide;Tear |
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