| Ultrastructural Features of Surgically Excised Idiopathic Subretinal Neovascular Membrane. |
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Moon Shin Lee, Soon Hyun Kim, Oh Woong Kwon |
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The Institute of Vision Research, Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea. |
| 수술 제거한 특발성 망막하신생혈관막의 투과전자현미경을 이용한 초미세구조 |
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이문신(Moon Shin Lee),김순현(Soon Hyun Kim),권오웅(Oh Woong Kwon) |
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| Abstract |
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Subretinal neovascular membrane is the direct cause of visual impairment in various macular lesions. The aim of this study is to understand the pathophysiology of subretinal neovascular membrane by ultrastructural study. Six cases of surgically excised idopathic subretinal neovascular membrane were examined ultrastructurally. The vascular channels, which were lined by endothelial cells and surrounded by pericyte or retinal pigment epithelium, were the main feature of subretinal neovascular membrane. Other cellular components were retinal pigment epithelium, myofibroblast containing melanosome, chronic inflammatory cells including macrophages, histiocytes, plasma cells and lymphocytes, fibrocytes and outer segments of photoreceptor cells. Considereing that the development of subretianl neovascular membrane is similar to the wound healing process, it is suggested that pathophysiology of subretinal neovascular membrane may be a process of abnormal wound healing. |
| Key Words:
Chronic inflammatory cell;Retinal pigment epithelium;Subretinal neovascular membrane;Wound healing |
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