Journal of the Korean Ophthalmological Society 1998;39(5):855-864.
Published online May 1, 1998.
Comparison of the Effect of Topical Steroid with Nonsteroidal Anti-inflammatory Drugs (NSAIDs) on Corneal Haze and Myopic Regression after Excimer Laser Photorefractive Keratectomy.
Sang Yul Choi, Seung Hee Baek, Jin Ho Chang, Won Ryang Wee, Jin Hak Lee
1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Ophthalmology, Seoul City Boramae Hospital, Seoul, Korea.
엑시머레이저 굴절교정각막절제술후 발생한 각막 혼탁과 근시퇴행에대한 비스테로이드성 항염증약물과 스테로이드 점안 효과의 비교
장진호 ( Jin Ho Chang ) , 이진학 ( Jin Hak Lee ) , 백승희 ( Seung Hee Baek ) , 최상열 ( Sang Yul Choi ) , 위원량 ( Won Ryang Wee )
Abstract
We wanted to evaluate the effects of topical nonsteroidal antiinflammatory drugs (NSAIDs) on refractive outcome and corneal haze after PRK(photorefractive keratectomy) according to the degree of myopia, and compare their effect with those of topical steroids. We divided our patients into moderate myopes (< OR = -6.0D) and high myopes (> OR = -6.0D), and each patient was randomly allocated to one of three drugs for initial management: 0.1% fluorometholone, 0.03% flurbiprofen, 0.1% diclofenac for 4 months after PRK. In moderate myopes, steroid group and NSAIDs group showed no difference in refraction after 6 months, and the subjective haze grading was consistently lower in steroid group after 3 weeks. In high myopes, steroid group and NSAIDs group showed no difference in both refraction and corneal haze after 6 months. Steroid group showed severe myopic regression or corneal haze less frequently than NSAID groups in high myopes. Topical NSAIDs are assumed to be less effective than topical steroids in reducing myopic regression and haze especially in high myopes after PRK.
Key Words: Nonsteroidal anti-inflammatory drugs;Steroid;Photorefractive keratectoiny;Corneal haze;Refraction


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