Clinical Analysis of Penetrating Keratoplasty in Herpes Simplex Keratitis.

Jeong, Jong Suk; Oh, Tae Hwa; Moon, Nam Ju

Original Article

Journal of the Korean Ophthalmological Society 1998;39(6):1111-1118.
Published online June 1, 1998.

Clinical Analysis of Penetrating Keratoplasty in Herpes Simplex Keratitis.

Jong Suk Jeong, Tae Hwa Oh, Nam Ju Moon

Department of Ophthalmology, National Medical Center, Seoul, Korea.

단순포진각막염 환자에서 각막이식술의 임상분석

정종석(Jong Suk Jeong),오태화(Tae Hwa Oh),문남주(Narn Ju Moon)

Abstract

We conducted a retrospective study of 20 penetrating keratoplasty (19patients) for corneal opacity due to herpes simplex keratitis from January 1992 to February 1997 at National Medical Center. We exaniined f requeuey of graft rejection and recurrence of herpetic keratitis after penetrating keratoplasty. The patients were grouped into control & treatinent, group according to the use of antivirial drug after penetrating keratoplasty and we examined the difference in rate of recurrence between two groups. The follow-up period was from 8 months to 68 months, mean follow-up period being 29.6 months. Graft rejection was seen in 3 eyes out of 20 eyes (15.0%) and recurrence was developed 3 eyes out of 20 eyes (15.0%). Recurrent herpetic keratitis developed in 15.4%(2 of 13) of the eyes in control group and 14.3% (1 of 7) of the eyes in treatment group. There was no statistically significant difference in recurrence rate between two groups (p)0.05). Postoperative prophylactic antiviral treatment is not associated with decreased rate of herpes simplex keratitis recurrence.

Key Words: Herpes simplex keratitis;Penetrating Keratoplasty;Recurrence;Rejection