The Effect of Mitomycin-C Eyedrop on Prevention of Internal Ostium Obstruction after Endonasal Dacryocystorhinostomy.

Lee, Tae Soo; Rhee, Kyuchul

Original Article

Journal of the Korean Ophthalmological Society 1998;39(9):1915-1920.
Published online September 1, 1998.

The Effect of Mitomycin-C Eyedrop on Prevention of Internal Ostium Obstruction after Endonasal Dacryocystorhinostomy.

Tae Soo Lee, Kyuchul Rhee

Department of Ophthalmology, College of Medicine Korea University, Seoul, Korea.

Topical Mitomycin C 안용액점안의 누낭비강문합술

이태수(Tae Soo Lee) , 이규철

Abstract

The authors evaluated the effect of topical mitomycin-C on the prevention of dacryocystorhinostomy internal ostium obstruction as antifibroblastic adjuvant. Topical 0.02% mitomycin-C(MMC) eyedrop was applied postoperatively to conjunctival sac of 75 patients who underwent endoscopic dacryocystorhinostomy-MMC group. MMC was instilled twice a day from postoperative 1 day for 7 days and from postoperative 4th week for 7 days. Properly matched another 75 patients without postoperative adjuvant MMC were compared with MMC goup regarding endoscopic findings, patency rates and other eyedrop complications. The internal ostium were patent in 85% in MMC group, and 77% in MMC and control group, respectively. Endoscopic examination of internal ostium showed mean final diameter of 3.4mm in MMC group and 2.5mm in control. There were no significant complications in MMC group except delayed epithelialization of nasal mucosa which had no relationship with surgical outcome.

Key Words: Topical mitomycin-C;Endoscopic dacryocystorhinostomy;Patency rates;Internal sotium;delayed epithelialization