| The Effect of 0/1% Dexamethasone on Repair Process of Eithelial Basement Membrane after Corneal Alkali Wounds: Electron Microscoic Examination. |
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Jung Won Yoo, Yang Keum Kang, Jang Hyun Chung |
1Department of Ophthalmology Ewha Medical Research Center, Ewha Women's University, Seoul, Korea.
2Division of Cell & Tissue Biology, Ewha Medical Research Center, Ewha Women's University, Seoul, Korea.
3Department of Ophthalmology, Inchon Mdedical. |
| 각막알칼리화상후 0.1% desamethasone 이 기저막 치유과정에 미치는 효과 : 전자현미경적 관찰 |
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유정원(Jung Won Yoo),강양금(Yang Keum Kang),정장현(Jang Hyun Chung) |
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| Abstract |
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An intact basement membrane which provides a firm attachment of basal epithelial cells to the maintain the corneal integrity in alkali wound healing. Despite many therapeutic trials tested, the fate of present investigation, the repair process of basal epithelium and its basement membrane was evaluated morphologically by utilizing a transmission electron microscope. New Zealand white rabbits, weighing 2.5kg, total of 16(16 eyes), were used in this experiment. Initial epithelial wounds were induced by applying a 5.5mm round filter paper, soaked in 1N NaOH, put on the central cornea for 60 seconds. Animals were divided into two groups and treated with 0.1% dexamethasone in the treated group and with balanced salt solution(BSS) in the control eyes q,i,d. for 8 weeks;. In control eyes, the basement membrane started focal disruption at 2 days, became the worst state at 4 weeks, and regained the normal integrity at 8 weeks after initial alkai damage, In dexamethansone-treated eyes. the basement membrance structure was fairly well visible up to 4 weeks and was almost completely disappeared at 8 weeks after intial alkali wounds. |
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