| Effects of Topically Applied Autologous Serum on Aqueous Biochemistry and Endothelial Healing Following Experimental Corneal Alkali Wounds. |
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Jung Won Yoo, Jnag Hyun Chung |
1Deapartment of Ophthalmology, Ewha Medical Research Center, Ewha University, Seoul, Korea.
2Deapartment of Anatomy, Ewha Medical Research Center, Ewha University, Seoul, Korea. |
| 가토 각막 알카리 화상에서 자가혈철 국소 점안이 방수의 화학 성분 변화와 각막 내피의 치유에 미치는 영향 |
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유정원(Jung Won Yoo),정장현(Jang Hyun Chung) |
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| Abstract |
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The effect of topically instilled autolohous serum on the healing of endothelium and change of aqueous chemical properties following alkali wounds were evaluated. New Zealand white rabbits, weighing 2.5KG, total 64(64 eyes), were used in this experiment. Standardized corneal alkali wounds were produced by applying a round filter paper of 5.5mm if diameter, soaked in 1N NaOH, to the central cornea for 60 seconds. Autologous serum in the treated group and balanced salt solution (BSS) in the control group were given 4 times per dat for 3 weeks. Endothelial defect areas and the concentrations of ascorbic acid, glucose and minerals in the aqueous humor were measured. Endothelial defect area was not significantly different between autologous serum-treated and control groups. The concentrations of ascorbic acid in the aqueous humor were aignificantly increased in the autologous serum-treated groups compared to the control groups. However, the concentrations of glucose, Na+, K+, Ca++ and Mg++ in the aqueous humor were not statistically different between two groups. |
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