The Effect of Continuous Intravitraal Irrigation(Lavaga) in Experimental Endophthalmitis.

Kang, Se Woong; Lee, Sang Woo

Original Article

Journal of the Korean Ophthalmological Society 1995;36(11):1980-1989.
Published online November 1, 1995.

The Effect of Continuous Intravitraal Irrigation(Lavaga) in Experimental Endophthalmitis.

Se Woong Kang, Sang Woo Lee

Department of Ophthalmology, College of Medicine, Chungbuk National University, Cheongju, Korea.

실험적 안내염에 대한 지속적인 유리체강 세척의 효과

이상우(Sang Woo Lee),강세웅(Se Woong Kang)

Abstract

The prognosis of infectious endophthalmitis has improved considerably in recent years with refinements in early diagnosis, proper antibiotic therapy and vitreous surgery. But the disease is still potentially catastrophic in spite of proper intervention. The purpose of this study was to evaluate the effect of continuous intravitreal irrigation(lavage) after vitrectomy and lensectomy in intractable endophthalmitis. We injected cultured Pseudomonas(1.5 X 10(5)organism/0.1ml) into the anterior chamber or vitreous cavity of 11 rabbits. In both experimental group(8 eyes) and control group(3 eyes), vitrectomy and lensectomy was done 12 hours after inoculation. In the experimental group, silicone tube was installed thru pars plana sclerotomy site as an infusion and drainage port. Vitreous cavity was irrigated for 3 days with normal saline(1000 ml/day) mixed with amikacin (10 mg/day) and dexamethasone(60 mg/day) via this silicone tube. In the control group, we injected 0.1 ml amikacin(100 microgram/0.1 ml) into vitreous cavity at the end of operation and on daily basis for 3 days. Both groups underwent subconjunctival(25 mg/day) and intramuscular (25 mg/kg/day) injection of amikacin for postoperative 3 days. Electroretinograms of two experimental eyes were taken to evaluate retinal toxicity. On postoperative 7th day, all eyes were enucleated to evaluate inflammatory and toxic changes with light microscope. Electroretinograms of experimental eyes became extinguished on the 7th postoperative day. But we observed that the experimental group showed less inflammatory change than control group in the vitreous cavity and retina.

Key Words: Amikacin;Dexamethasone;Endophthalmitis;Intravitreal irrigation