Efficacy of High Dose Corticosteroid Therapy in Experimental Traumatic Optic Neuropathy.

Lee, Sang Yeul; Kim, Sung Joo; Kim, Hye Young; Ham, Chang Hoon; Cho, Kang Won; Kim, Tai Seung

Original Article

Journal of the Korean Ophthalmological Society 1995;36(12):2213-2217.
Published online December 1, 1995.

Efficacy of High Dose Corticosteroid Therapy in Experimental Traumatic Optic Neuropathy.

Sang Yeul Lee, Sung Joo Kim, Hye Young Kim, Chang Hoon Ham, Kang Won Cho, Tai Seung Kim

¹Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea.
²Department of Pathlogy, College of Medicine, Yonsei University, Seoul, Korea.

실험적으로 유발된 외상성 시신경증에 대한 고용량 부신피질호르몬제의 치료효과

김성주(Seong Ju Kim),이상렬(Sang Yeul Lee),김혜영(Hye Young Kim),함창훈(Chang Hoon Ham),조강원(Kang Won Cho),김태승(Tai Seung Kim)

Abstract

We investigated the efficacy of high dose corticosteroid therapy in the treatment of traumatic optic-neuropathy. We experimentally damaged the optic nerves of six white rabbits with a Hartman mosquito. Three of the rabbits were intravenously injected with 0.25mg/kg dexamethasone every six hours for a 48 hour period. The others were used as controls. In both groups, the optic nerves were removed after one month and stained with Hematoxyline-eosin, then examined microscopically. No histological differences were found in either the control or the experimental group.

Key Words: Corticosteroid therapy;Optic nerve;Traumatic optic-neuropathy