The Effect of Topically Applied Sodium-hyaluronic acid(Na-HA) on Corneal Epithelial Healing.

Chung, Jang Hyun; Kim, Eun Ah; Kwon, Kae Rang; Ahn, Chung Sook

Randomized Controlled Trial

Journal of the Korean Ophthalmological Society 1996;37(6):921-926.
Published online June 1, 1996.

The Effect of Topically Applied Sodium-hyaluronic acid(Na-HA) on Corneal Epithelial Healing.

Jang Hyun Chung, Eun Ah Kim, Kae Rang Kwon, Chung Sook Ahn

Department of Ophthalmology, Medical Research Center, Ewha Womans University, Seoul, Korea.

Na-hyaluronic acid 국소점안이 각막상피 찰과상 치유에 미치는 영향

정장현(Jang Hyun Chung),김은아(Eun Ah Kim),안정숙(Chung Sook Ahn),권계랑(Kae Rang Kwon)

Abstract

To evaluate the effect of Na-hyaluronic acid (Na-HA) on corneal epithelial wound healing, twenty admitted patients (twenty-four eyes) with corneal epithelial abrasion were randomly divided into 2 groups. 1% Na-HA was given 4 times daily to 12 treated eyes while 12 control cases received antibiotic ointment therapy. Epithelial defect area was photodocumented by 6-12 hours interval and individual healing rates were calculated by linear regression analysis. The healing rate of 1% Na-HA treated cornea was 1.02 +/- 0.26mm2/hour and that of the control eyes was 0.67 +/- 0.19 mm/hour(p<0.05). The result suggests that topically applied Na-HA enhances epithelial re~surfacing when compared to the antibiotics ointment.

Key Words: Corneal epithelium;Healing rate;1% Na-hyaluronic acid;Morphometry